Isotretinoin, CAS 4759-48-2

Formulation: A crystalline solid

Formal Name: 13-cis-retinoic acid

Purity: ≥98%

Formula Markup: C20H28O2

Formula Weight: 300,4

Shelf life (days): 1460

CAS Number: 4759-48-2

Notes: Isotretinoin is a retinoid that is converted in vivo into all-trans retinoic acid (Item No. 11017) and has diverse biological activities.{40199,39853,39854,39855} It increases the doubling time and transcription of retinoic acid receptor β (RARβ) mRNA in Hep2, FaDu, CCL-17, SCC-9, SCC-15, and SCC-25 human oral squamous cell carcinoma cells when used at a concentration of 1 μM.{39853} Isotretinoin inhibits proliferation of primary human sebocytes (IC50 = 10 μM).{39854} It also decreases triglyceride, stearyl ester, and free fatty acid synthesis and modulates keratin expression in primary human sebocytes at a concentration of 0.1 μM. Isotretinoin (2 mg/kg per day) reduces chronic rejection damage and decreases mRNA expression of IFN-γ and IL-10 in allografts in chronic Fisher344➛Lewis transplant mice, an allograft nephropathy model.{39855} It also slows rod and cone recovery and prevents light-induced photoreceptor damage in an albino rat model of photoreceptor degeneration when administered at a dose of 40 mg/kg.{39856} Formulations containing isotretinoin have been used in the treatment of severe recalcitrant nodular acne.

• Artikelnummer: CAY21648-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 21648-1
• Green Labware: Nein
• Verpackungseinheit: 1 g
• Mengeneinheit: STK