ITE, CAS 448906-42-1

Formulation: A solid

Formal Name: 2-(1H-indol-3-ylcarbonyl)-4-thiazolecarboxylic acid, methyl ester

Purity: ≥98%

Formula Markup: C14H10N2O3S

Formula Weight: 286,3

Shelf life (days): 1460

CAS Number: 448906-42-1

Notes: ITE is an endogenous aryl hydrocarbon receptor (AhR) agonist.{52676} It binds to AhR (Kd = 65 nM) and induces AhR-dependent transcription in luciferase reporter assays when used at a concentration of 0.01 µM. ITE (1 µM) inhibits anti-CD40- and IL-4-induced differentiation of isolated mouse splenic B cells, as well as proliferation and migration of SKOV3 ovarian cancer cells.{52677,52678} In vivo, ITE (200 µg/animal, i.p.) reduces retinal detachment and ocular inflammatory cell infiltration in a mouse model of experimental autoimmune uveitis induced by complete Freund's adjuvant (CFA) and M. tuberculosis.{52679} ITE (80 mg/kg, i.p.) reduces tumor growth by 39% in an OVCAR-3 mouse xenograft model.{52678}

• Artikelnummer: CAY25355-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 25355-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK