Ivabradine-d3 (hydrochloride), CAS 1217809-61-4

Formulation: A solid

Formal Name: (S)-3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl-d3)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one, monohydrochloride

Purity: ≥99% deuterated forms (d1-d3)

Formula Markup: C27H33D3N2O5 • HCl

Formula Weight: 508,1

Shelf life (days): 1460

CAS Number: 1217809-61-4

Notes: Ivabradine-d3 is intended for use as an internal standard for the quantification of ivabradine (Item No. 15868) by GC- or LC-MS. Ivabradine is a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker that blocks the mixed sodium/potassium inward funny current (If) in HEK293 cells expressing mouse HCN1, human HCN2, and human HCN4 (EC50s = 4.5, 4.52, and 4.28 μM, respectively).{25789} In vivo, ivabradine (10 mg/kg per day) reduces heart rate, incidence of ventricular tachycardia and ventricular fibrillation, and arrhythmic mortality in a rat model of myocardial infarction.{37776} Formulations containing ivabradine have been used in the treatment of heart failure and angina.

• Artikelnummer: CAY25711-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 25711-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung