JNJ-16259685, CAS 409345-29-5

Formulation: A solid

Formal Name: (3,4-dihydro-2H-pyrano[2,3-b]quinolin-7-yl)(cis-4-methoxycyclohexyl)-methanone

Purity: ≥95%

Formula Markup: C20H23NO3

Formula Weight: 325,4

Shelf life (days): 1460

CAS Number: 409345-29-5

Notes: JNJ-16259685 is an antagonist of metabotropic glutamate receptor 1a (mGluR1a; Ki = 0.34 nM in CHO(dHFr-) cell membranes expressing the rat receptor).{63296} It is selective for mGluR1a over mGluR5, -2, -3, -4, and -6, as well as a panel of neurotransmitter receptors, ion channels, and transporters, at 10 µM. JNJ-16259685 inhibits glutamate-induced inositol phosphate accumulation in primary rat cerebellar neurons with an IC50 value of 1.73 nM. It increases drinking in the Vogel punished drinking task, indicating anxiolytic-like activity, when administered at doses of 2.5, 5, or 10 mg/kg.{63297}

• Artikelnummer: CAY35377-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 35377-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK