JNJ-37822681 (hydrochloride), CAS 2108806-02-4

Formulation: A solid

Formal Name: N-[1-[(3,4-difluorophenyl)methyl]-4-piperidinyl]-6-(trifluoromethyl)-3-pyridazinamine, dihydrochloride

Purity: ≥98%

Formula Markup: C17H17F5N4 • 2HCl

Formula Weight: 445,3

Shelf life (days): 1460

CAS Number: 2108806-02-4

Notes: JNJ-37822681 is a dopamine D2L receptor antagonist (Ki = 0.158 µM).{67179} It is selective for dopamine D2L receptors over dopamine D1 and D3, α1-adrenergic, and histamine H1 receptors, and the serotonin (5-HT) receptor subtypes 5-HT2A and 5-HT2C in radioligand binding assays (Kis = >3, 1.159, >5, 4.931, 2.896, and >4 µM, respectively). JNJ-37822681 inhibits apomorphine-induced stereotypy and D-amphetamine-induced hyperlocomotion in rat models of psychosis (ED50s = 0.19 and 1 mg/kg, respectively).

• Artikelnummer: CAY37428-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37428-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK
• Methode: Reinstoffe