JNJ-47965567, CAS 1428327-31-4

Formulation: A crystalline solid

Formal Name: 2-(phenylthio)-N-[[tetrahydro-4-(4-phenyl-1-piperazinyl)-2H-pyran-4-yl]methyl]-3-pyridinecarboxamide

Purity: ≥98%

Formula Markup: C28H32N4O2S

Formula Weight: 488,6

Shelf life (days): 1460

CAS Number: 1428327-31-4

Notes: JNJ-47965567 is a selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel. Activation of P2X receptors by BzATP (Item No. 15577) induces calcium flux, which is reduced by JNJ-47965567 in 1321N1 cells transfected with recombinant P2X7 human, macaque, dog, rat, or mouse protein with pIC50s of 8.3, 8.6, 8.5, 7.2, or 7.5, respectively.{34131} JNJ-47965567 suppresses neonatal hypoxia-induced seizures in mice and has some anticonvulsant properties in rats.{34134,34132} It also reduces spontaneous seizures in epileptic mice even after treatment is stopped.{34133}

• Artikelnummer: CAY21895-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 21895-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK