JP-1302 (hydrochloride hydrate)

Formulation: A solid

Formal Name: N-[4-(4-methyl-1-piperazinyl)phenyl]-9-acridinamine, dihydrochloride, hydrate

Purity: ≥98%

Formula Markup: C24H24N4 • 2HCl [XH2O]

Formula Weight: 441,4

Shelf life (days): 1460

Notes: JP-1302 is an antagonist of α2-adrenergic receptors (α2-ARs) that is selective for α2C-ARs over α2A- and α2B-ARs (Kis = 28, 3,150, and 1,470 nM, respectively).{42543} It reduces immobility time in the forced swim test in mice when administered at doses of 1, 3, and 10 µmol/kg. JP-1302 (5 mg/kg) reverses phencyclidine-induced decreases in prepulse inhibition of the acoustic startle response in rats. It dose-dependently reduces haloperidol-induced bradykinesia and catalepsy in mice.{42544} JP-1302 (0.3 mg/kg) also increases systolic blood pressure in rats.{42545}

• Artikelnummer: CAY25974-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 25974-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK