(+)-Kavain, CAS 500-64-1

Formulation: A crystalline solid

Formal Name: (6R)-5,6-dihydro-4-methoxy-6-[(1E)-2-phenylethenyl]-2H-pyran-2-one

Purity: ≥98%

Formula Markup: C14H14O3

Formula Weight: 230,3

Shelf life (days): 1460

CAS Number: 500-64-1

Notes: Kavain is a kavalactone and the major constituent of the pepper plant kava (P. methysticum) and has diverse biological activities.{46119,46120,46121,46122} It is a positive allosteric modulator of α4β2δ subunit-containing GABAA receptors with EC50 values of 25 and 59 µM in the presence and absence of 300 µM kavain, respectively, in Xenopus oocytes expressing human receptors.{46119} Kavain reduces growth of WPMY-1 prostate cancer cells (IC50 = 5.2 µg/ml).{46120} It reduces LPS-induced TNF-α production in primary murine macrophages in a concentration-dependent manner.{46121} In vivo, kavain (1 mg/animal) reduces hind paw swelling and TNF-α production in wild-type, but not Erk-/-, mice in a mouse model of collagen-induced arthritis. Kavain also reduces acetic acid-induced abdominal constrictions in mice (ED50= 15.71 mg/kg).{46122}

• Artikelnummer: CAY26524-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 26524-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK