Formulation: A solid
Formal Name: 7-[(2-benzothiazolylamino)[4-(difluoromethoxy)phenyl]methyl]-8-quinolinol
Purity: ≥98%
Formula Markup: C24H17F2N3O2S
Formula Weight: 449,5
Shelf life (days): 1460
CAS Number: 446826-86-4
Notes: KIN1400 is a small molecule activator of the RIG-1-like receptor (RLR) pathway that has antiviral activity.{41564} It induces expression of the innate immune genes RIG-1, MDA5, IFIT1, IFIT2, IFITM1, OAS3, and Mx1 in THP-1 cells stimulated with phorbol 12-myristate 13-acetate (PMA; Item No. 10008014). KIN1400 (20 μM) reduces West Nile and dengue viral RNA levels in HEK293 and Huh7 cells, respectively. It also inhibits hepatitis C virus (HCV) replication in a concentration-dependent manner in Huh7 cells.