KN-93 (phosphate), CAS 1188890-41-6

Formulation: A crystalline solid

Formal Name: N-[2-[[[(2E)-3-(4-chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxy-benzenesulfonamide, monophosphate

Purity: ≥98%

Formula Markup: C26H29ClN2O4S • H3PO4

Formula Weight: 599

Shelf life (days): 1460

CAS Number: 1188890-41-6

Notes: KN-93 (phosphate) is a potent and selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII) (Ki = 370 nM), inhibiting both the α- and β-subunits of CaMKII.{17325} It does not have significant effects on cAMP-dependent protein kinase, Ca2+/phospholipid-dependent protein kinase, myosin light chain kinase, or Ca2+ phosphodiesterase activity. It inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM).{17326} KN-93 can block voltage-gated potassium (Kv) channels when applied extracellularly, independent of its CaMKII action.{33674} More recently, KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca2+-dependent activation of HIF-1α in colon cancer cells.{17327,17328,17329}

• Artikelnummer: CAY21472-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 21472-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK