Kynurenic Acid-d5, CAS 350820-13-2

Formulation: A solid

Formal Name: 4-hydroxy-2-quinoline-3,5,6,7,8-d5-carboxylic acid

Purity: ≥99% deuterated forms (d1-d5)

Formula Markup: C10H2D5NO3

Formula Weight: 194,2

Shelf life (days): 1460

CAS Number: 350820-13-2

Notes: Kynurenic acid-d5 is intended for use as an internal standard for the quantification of kynurenic acid (Item No. 16792) by GC- or LC-MS. Kynurenic acid is an active metabolite of tryptophan (Item No. 29600 / 31210).{27403} It is formed from tryptophan via a kynurenine (Item No. 11305) intermediate by kynurenine aminotransferases (KATs). Kynurenic acid is an antagonist of the NMDA and AMPA receptors as well as α7 nicotinic acetylcholine receptors (nAChRs; EC50s = 235, 101, and 7 µM, respectively).{27404} It is also an agonist of the aryl hydrocarbon receptor (AhR) and G protein-coupled receptor 35 (GPR35; EC50s = 1.4 and 39 µM, respectively). It prevents lesioned hemisphere weight loss in a neonatal rat model of cerebral hypoxic-ischemia induced by carotid artery ligation when administered at a dose of 300 mg/kg.{57914} Kynurenic acid (1 and 5 mg/ml) is protective against rhabdomere neurodegeneration in the eye in an Htt93Q transgenic Drosophila model of Huntington’s disease.{60163} Levels of kynurenic acid in cerebrospinal fluid are increased in patients with schizophrenia.{57915}

• Artikelnummer: CAY36306-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36306-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung