L-655,708, CAS 130477-52-0

Formulation: A solid

Formal Name: (13aS)-11,12,13,13a-tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, ethyl ester

Purity: ≥98%

Formula Markup: C18H19N3O4

Formula Weight: 341,4

Shelf life (days): 1460

CAS Number: 130477-52-0

Notes: L-655,708 is a ligand for α5 subunit-containing GABAA receptors that has nootropic activity.{56024} It selectively binds to α5 subunit-containing GABAA receptors over α1, α2, or α3 subunit-containing receptors (Kis = 1, 70, 48, and 31 nM, respectively, for recombinant human receptors). L-655,708 (10 nM) increases the amplitude of extracellular post-synaptic potentials (EPSPs) in mouse hippocampal slices. In vivo, L-655,708 (1.5 mg/animal) decreases the latency to find the platform and increases time spent in the target quadrant in the Morris water maze in mice.

• Artikelnummer: CAY30322-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 30322-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK