L-Kynurenine-d4, CAS 2672568-86-2

Formulation: A solid

Formal Name: (S)-2-amino-4-(2-aminophenyl-3,5-d2)-4-oxobutanoic-3,3-d2 acid

Purity: ≥99% deuterated forms (d1-d4)

Formula Markup: C10H8D4N2O3

Formula Weight: 212,2

Shelf life (days): 1460

CAS Number: 2672568-86-2

Notes: L-Kynurenine-d4 is intended for use as an internal standard for the quantification of kynurenine by GC- or LC-MS. L-Kynurenine is an active metabolite of tryptophan (Item Nos. 29600 / 31210).{20572} It is formed from tryptophan via tryptophan 2,3-dioxygenase (TDO) or indoleamine 2,3-dioxygenase (IDO). L-Kynurenine binds to the aryl hydrocarbon receptor (AhR; Kd = ~4 µM) and increases the activity of ethoxyresorufin-O-deethylase (EROD) in H-4-II-E rat hepatoma cells (EC50 = 12.3 µM).{20319} It decreases intracellular concentrations of NAD+ (Item No. 16077) in, and increases lactate dehydrogenase (LDH) activity in the supernatant of, primary human astrocytes and neurons in a concentration-dependent manner.{42854} L-Kynurenine in combination with IFN-γ reduces lung injury induced by A. fumigatus infection in the p47phox-/- mouse model of chronic granulomatous disease.{15340}

• Artikelnummer: CAY36307-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36307-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung