Labetalol-d5 (hydrochloride), CAS 2713514-78-2

Formulation: A solid

Formal Name: 2-hydroxy-5-[1-hydroxy-2-[(1-methyl-3-(phenyl-d5)propyl)amino]ethyl]-benzamide, monohydrochloride

Purity: ≥99% deuterated forms (d1-d5)

Formula Markup: C19H19D5N2O3 • HCl

Formula Weight: 369,9

Shelf life (days): 1460

CAS Number: 2713514-78-2

Notes: Labetalol-d5 is intended for use as an internal standard for the quantification of labetalol (Item No. 20249) by GC- or LC-MS. Labetalol is an adrenergic receptor (AR) antagonist.{54376} It inhibits agonist-induced contraction of rabbit aortic strips, decreases in contractile force in isolated guinea pig atria, and vasorelaxation in isolated guinea pig tracheal strips (pA2s = 6.99, 7.68, and 7.54, respectively), tissues that endogenously express high levels of α-, β1-, and β2-ARs, respectively. Labetalol (2.5-25 mg/kg) reduces blood pressure in spontaneously hypertensive rats. It reduces blood pressure in DOC-salt rats, two-kidney Goldblatt rats, and one-kidney dogs. Labetalol (5 mg/kg) reduces infarct size in a dog model of myocardial infarction induced by occlusion of the left anterior descending artery. Topical administration of labetalol (0.25-1% v/v) reduces intraocular pressure in rabbits. Formulations containing labetalol have been used in the treatment of hypertension.

• Artikelnummer: CAY31609
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 31609-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung