Lacidipine, CAS 103890-78-4

Formulation: A solid

Formal Name: 4-[2-[(1E)-3-(1,1-dimethylethoxy)-3-oxo-1-propen-1-yl]phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid, 3,5-diethyl ester

Purity: ≥98%

Formula Markup: C26H33NO6

Formula Weight: 455,5

Shelf life (days): 1460

CAS Number: 103890-78-4

Notes: Lacidipine is a dihydropyridine L-type calcium channel blocker.{47591} It induces relaxation of isolated rat aorta and inhibits calcium-induced contraction of rabbit ear artery (pA2 = 9.4). It also induces relaxation of calcium-induced contractions in isolated rat colon and bladder and guinea pig trachea (IC50s = 6.7, 6, and 7.8 nM, respectively). Lacidipine induces negative inotropy in isolated guinea pig ventricular strips (IC50 = 110 nM). It reduces mean blood pressure in spontaneously hypertensive rats (ED25 = 0.35 mg/kg) and in renal hypertensive dogs (ED25 = 0.22 mg/kg) with a transient increase in heart rate. Lacidipine inhibits copper-induced oxidation of isolated human LDL when used at concentrations of 1 and 5 µM.{47592} It reduces the extension of aortic atheromatous lesions and decreases renal injury in ApoE-/- mice in a model of Western diet-induced atherosclerosis.{47593}

• Artikelnummer: CAY28270-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28270-1
• Green Labware: Nein
• Verpackungseinheit: 1 g
• Mengeneinheit: STK