Lanifibranor, CAS 927961-18-0

Formulation: A crystalline solid

Formal Name: 1-(6-benzothiazolylsulfonyl)-5-chloro-1H-indole-2-butanoic acid

Purity: ≥98%

Formula Markup: C19H15ClN2O4S2

Formula Weight: 434,9

Shelf life (days): 1460

CAS Number: 927961-18-0

Notes: Lanifibranor is an agonist of peroxisome proliferator-activated receptors (PPARs) with EC50 values of 1,537, 866, and 206 nM for human recombinant PPARα, PPARβ, and PPARγ, respectively, for transactivation activity.{42553} It increases β-oxidation in Huh-7 and C2C12 cells when used at concentrations of 1 and 3 µM, respectively, and increases the expression of the PPARγ target genes adipocyte protein 2 (aP2) and adiponectin in adipocytes. Lanifibranor reduces plasma glucose and triglyceride levels in a db/db mouse model of type 2 diabetes when administered at doses of 10 and 30 mg/kg for five days. It also increases plasma adiponectin levels and decreases collagen deposition in a carbon tetrachloride-induced mouse model of non-alcoholic steatohepatitis (NASH).

• Artikelnummer: CAY25572-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 25572-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK