Lasofoxifene, CAS 180916-16-9

Formulation: A crystalline solid

Formal Name: (5R,6S)-5,6,7,8-tetrahydro-6-phenyl-5-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-2-naphthalenol

Purity: ≥98%

Formula Markup: C28H31NO2

Formula Weight: 413,6

Shelf life (days): 1460

CAS Number: 180916-16-9

Notes: Lasofoxifene is a third-generation, non-steroidal selective estrogen receptor modulator (SERM). It selectively binds to human ERα with an IC50 value of 1.5 nM and inhibits bone loss in ovariectomized rats.{28785} In clinical studies of postmenopausal osteoporosis, 0.5 mg/day lasofoxifene was associated with reduced risks of nonvertebral and vertebral fractures, ER-positive breast cancer, coronary heart disease, and stroke but an increased risk of venous thromboembolic events.{28786,28787} Lasofoxifene has also been shown to act as an inverse agonist at the CB2 cannabinoid receptor, indicating its potential to be repurposed as a therapeutic for indications wherein CB2 is a target.{28788}

• Artikelnummer: CAY21754-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 21754-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK