LIT-927, CAS 2172879-52-4

Formulation: A solid

Formal Name: 4-(4-chlorophenyl)-6-(4-hydroxy-3-methoxyphenyl)-2(1H)-pyrimidinone

Purity: ≥98%

Formula Markup: C17H13ClN2O3

Formula Weight: 328,8

Shelf life (days): 1460

CAS Number: 2172879-52-4

Notes: LIT-927 is an orally bioavailable neutraligand that binds to chemokine (C-X-C motif) ligand 12 (CXCL12; Ki = 267 nM in a FRET-based binding assay).{50130} It is selective for inhibiting calcium accumulation induced by CXCL12 over that induced by chemokine (C-C motif) ligand 17 (CCL17), CCL22, CCL5, and CCL2 at 10 µM. It inhibits pulmonary artery smooth muscle cell and pericyte migration in vitro.{52003} LIT-927 (100 mg/kg per day) inhibits increases in serum levels of CXCL12, as well as reduces total pulmonary vascular resistance and remodeling of pulmonary arterioles, in a rat model of pulmonary hypertension induced by monocrotaline (Item No. 16666). It inhibits allergen-induced eosinophil infiltration into the lung by 62% in a mouse model of allergic airway hypereosinophilia when administered at an oral dose of 1,400 µmol/kg.

• Artikelnummer: CAY28436-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28436-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK