LM22B-10, CAS 342777-54-2

Formulation: A crystalline solid

Formal Name: 2,2',2'',2'''-[[(4-chlorophenyl)methylene]bis(4,1-phenylenenitrilo)]tetrakis-ethanol

Purity: ≥98%

Formula Markup: C27H33ClN2O4

Formula Weight: 485

Shelf life (days): 1460

CAS Number: 342777-54-2

Notes: LM22B-10 is an activator of neurotrophic tyrosine kinase receptor 2 (TrkB) and -3 (TrkC).{45544} It is selective for TrkB and TrkC over TrkA in NIH3T3 cells but does inhibit the serotonin (5-HT) receptor subtype 5-HT5A and the dopamine transporter by greater than 50% in a panel of 57 G protein-coupled peptide and nonpeptide receptors at 10 µM. LM22B-10 increases survival, neurite length, and dendritic spine density of primary mouse embryonic hippocampal neurons when used at a concentration of 1 µM. LM22B-10 (50 mg/kg i.p. in combination with an intranasal dose of 5 mg/kg per day) also increases hippocampal neuron dendritic spine density in aged mice.

• Artikelnummer: CAY29037-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29037-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK