LMB763, CAS 1773489-72-7

Formulation: A solid

Formal Name: 4-[[[(8-chloro-1,4-dihydro-1-methyl[1]benzopyrano[4,3-c]pyrazol-3-yl)carbonyl](phenylmethyl)amino]methyl]-benzoic acid

Purity: ≥98%

Formula Markup: C27H22ClN3O4

Formula Weight: 487,9

Shelf life (days): 1460

CAS Number: 1773489-72-7

Notes: LMB763 is a partial agonist of the farnesoid X receptor (FXR; EC50 = 7 nM).{50981} It is selective for FXR over a panel of enzymes, ion channels, nuclear receptors, and G protein-coupled receptors, including the androgen receptor, estrogen receptor α (ERα), and G protein-coupled bile acid receptor 1 (GPBAR1; EC50s = >30, >30, and >80 µM, respectively). LMB763 induces expression of the FXR target genes encoding the bile salt export pump and short heterodimer partner in isolated rat hepatocytes in a concentration-dependent manner. It decreases non-alcoholic fatty liver disease (NAFLD) scores and liver fibrosis in a rat model of non-alcoholic steatohepatitis (NASH).

• Artikelnummer: CAY30184-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 30184-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK