Lodoxamide, CAS 53882-12-5

Formulation: A solid

Formal Name: 2,2'-[(2-chloro-5-cyano-1,3-phenylene)diimino]bis[2-oxo-acetic acid]

Purity: ≥95%

Formula Markup: C11H6ClN3O6

Formula Weight: 311,6

Shelf life (days): 1460

CAS Number: 53882-12-5

Notes: Lodoxamide is a potent agonist of GPR35 with an EC50 value of 1.61 nM in a β-arrestin-2 interaction assay using CHO-K1 cells expressing the human receptor.{38490} It inhibits histamine release induced by compound 48/80 (Item No. 22173), anti-IgE, or A23187 (Item No. 11016) in isolated rat peritoneal mast cells (IC50s = 0.1-50 µM) and inhibits A23187-induced calcium influx in mast cells.{38491} It reduces antigen-induced histamine release from rat conjunctival tissue by 46% in vitro when used at a concentration of 10 µg/ml.{38492} Lodoxamine (0.1 and 10%, w/v) reduces the immediate hypersensitivity response in rat conjunctiva in vivo in a dose-dependent manner and reduces mast cell degranulation in a topical ovalbumin challenge.{38492,38493} Formulations containing lodoxamide have been used in the treatment of vernal conjunctivitis and keratitis.

• Artikelnummer: CAY23994-250
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23994-250
• Green Labware: Nein
• Verpackungseinheit: 250 mg
• Mengeneinheit: STK