Formulation: A solid
Formal Name: 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl-2,3,5,6-d4]methyl]-1H-imidazole-5-methanol
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C22H19ClD4N6O
Formula Weight: 426,9
Shelf life (days): 1460
CAS Number: 1030937-27-9
Notes: Losartan-d4 is intended for use as an internal standard for the quantification of losartan (potassium salt) (Item No. 10006594) by GC- or LC-MS. Losartan is an antagonist of the angiotensin (AT) II receptor subtype AT1 with a Ki value of 5-20 nM.{12997} It has an attenuating effect on vein graft atherosclerosis in rabbits and effectively reduces arterial blood pressure in rats.{12998,13089} Formulations containing losartan have been used to control hypertension while protecting renal function.{12996}