Loxapine-d8, CAS 1189455-63-7

Formulation: A solid

Formal Name: 2-chloro-11-(4-methylpiperazin-1-yl-2,2,3,3,5,5,6,6-d8)dibenzo[b,f][1,4]oxazepine

Purity: ≥99% deuterated forms (d1-d8)

Formula Markup: C18H10ClD8N3O

Formula Weight: 335,9

Shelf life (days): 1460

CAS Number: 1189455-63-7

Notes: Loxapine-d8 is intended for use as an internal standard for the quantification of loxapine (Item No. 20760) by GC- or LC-MS. Loxapine is an atypical antipsychotic.{24253} It binds to the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 (Kis = 2,456, 7.7, 9.5, 32, and 87.2 nM, respectively), as well as dopamine D2, histamine H1, and M3 muscarinic acetylcholine receptors (Kis = 12, 7, and 122 nM, respectively). Loxapine also binds to α1A-, α2A-, α2B-, and α2C-adrenergic receptors (Kis = 31, 150.8, 107.6, and 79.9 nM, respectively). Formulations containing loxapine have been used in the treatment of schizophrenia.

• Artikelnummer: CAY33537-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33537-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung