Lu AA33810, CAS 304008-29-5

Formulation: A solid

Formal Name: N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide

Purity: ≥98%

Formula Markup: C19H25N3O2S3

Formula Weight: 423,6

Shelf life (days): 1460

CAS Number: 304008-29-5

Notes: Lu AA33810 is an antagonist of neuropeptide Y (NPY) receptor Y5 (Ki = 1.5 nM for the human receptor).{61395} It is selective for Y5 over Y1, Y2, and Y4 (Kis = >10 µM for all in HEK293 membranes expressing rat receptors). Lu AA33810 also binds the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT2B (Kis = 478 and 247 nM, respectively). It inhibits NPY-induced calcium mobilization and cAMP accumulation in COS-7 and HEK293 cells expressing the rat Y5 receptor, respectively, in a concentration-dependent manner. Lu AA33810 (10 mg/kg) increases social interaction time in a social exploration test, as well as decreases immobility time in the forced swim test, in rats, indicating anxiolytic- and antidepressant-like activities, respectively.

• Artikelnummer: CAY32913-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 32913-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK