Lu AF21934, CAS 1445605-23-1

Formulation: A crystalline solid

Formal Name: N1-(3,4-dichlorophenyl)-1S,2R-cyclohexanedicarboxamide

Purity: ≥98%

Formula Markup: C14H16Cl2N2O2

Formula Weight: 315,2

Shelf life (days): 1460

CAS Number: 1445605-23-1

Notes: Lu AF21934 is a positive allosteric modulator (PAM) of metabotropic glutamate receptor 4 (mGluR4; EC50 = 500 nM for the human receptor in a FLIPR assay).{48374} It is selective for mGluR4 over mGluR6 (EC50 = 7 μM) and a panel of 73 CNS ion channels, G protein-coupled receptors (GPCRs), and enzymes at 10 μM. Lu AF21934 (12 mg/kg) reduces marble burying behavior and stress-induced hyperthermia in mice, indicating anxiolytic-like activity, but also reduces locomotor activity. It inhibits MK-801- and amphetamine-induced hyperactivity in mice and prevents MK-801-induced decreases in social interaction in rats.{48375} Lu AF21934 (0.5 and 2.5 mg/kg) also reduces harmaline-induced hyperactivity, but not tremor, in rats.{48376}

• Artikelnummer: CAY27045-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 27045-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK