LY255283, CAS 117690-79-6

Formulation: A crystalline solid

Formal Name: 1-[5-ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-yl)heptyl]oxy]phenyl]-ethanone

Purity: ≥98%

Formula Markup: C19H28N4O3

Formula Weight: 360,5

Shelf life (days): 365

CAS Number: 117690-79-6

Notes: Antagonists of the chemotactic and inflammatory lipoxygenase product leukotriene B4 (LTB4) have been potential drug development targets for several years.{4552,4553} The tetrazole LY255283 is a competitive antagonist of the BLT2 receptor. It displaces radiolabeled LTB4 from guinea pig lung membrane, with an IC50 of about 100 nM.{2084} LY255283 exhibits IC50 values of ~950 nM and >10 µM at human recombinant BLT2 and BLT1 receptors, respectively.{9270} LY255283 inhibits eosinophil chemotaxis by 80% at a concentration of 10 µM, and inhibits the binding of radiolabeled LTB4 to eosinophil membranes with an IC50 of 260 nM.{4552}

• Artikelnummer: CAY70715-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 70715-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK