LY2562175, CAS 1103500-20-4

Formulation: A crystalline solid

Formal Name: 6-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methoxy]-1-piperidinyl]-1-methyl-1H-indole-3-carboxylic acid

Purity: ≥95%

Formula Markup: C28H27Cl2N3O4

Formula Weight: 540,4

Shelf life (days): 1460

CAS Number: 1103500-20-4

Notes: LY2562175 is a farnesoid X receptor (FXR) agonist (EC50 = 193 nM in a reporter assay).{48622} It is selective for FXR over the glucocorticoid, androgen, mineralocorticoid, and progesterone receptors in HEK293 cells overexpressing the human receptors (EC50s = >10 µM for all in a radioligand binding assay). LY2562175 increases the interaction between FXR and steroid receptor coactivator 1 (SRC-1) with an EC50 value of 121 nM in a cell-free assay. It reduces plasma triglyceride and total cholesterol levels in LDL receptor-null mice (ED50s = 3.4 and 2 mg/kg, respectively). LY2562175 also decreases plasma LDL and increases HDL levels in Zucker diabetic fatty (ZDF) rats when administered at doses of 3, 10, and 30 mg/kg for nine days.

• Artikelnummer: CAY28912-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28912-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK