Formulation: A crystalline solid
Formal Name: 1-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-1,3-dihydro-3,3-dimethyl-2H-indol-2-one, monohydrochloride
Purity: ≥98%
Formula Markup: C24H27FN2O2 • HCl
Formula Weight: 430,9
Shelf life (days): 1460
CAS Number: 192927-92-7
Notes: LY310762 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT1D (Ki = 249 nM for guinea pig receptors).{40403} It is selective for 5-HT1D over the 5-HT1B receptor, where it inhibits binding of radiolabeled citalopram by only 32% when used at a concentration of 1,000 nM. LY310762 potentiates 5-HT (Item No. 14332) release stimulated by potassium in guinea pig cortex (EC50 = 31 nM). It also reverses vasodilation induced by 5-HT in rat kidney perfused by phenylephrine (Item Nos. 17205 / 18619) when administered at a dose of 1 mg/kg.{40402}