LY334370 (hydrochloride), CAS 199673-74-0

Formulation: A crystalline solid

Formal Name: 4-fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]-benzamide, monohydrochloride

Purity: ≥98%

Formula Markup: C21H22FN3O • HCl

Formula Weight: 387,9

Shelf life (days): 1460

CAS Number: 199673-74-0

Notes: LY334370 is an agonist of the serotonin (5-HT) receptor subtype 5-HT1F (Kd = 0.446 nM).{52208} It is selective for 5-HT1F over other G protein-coupled 5-HT receptor subtypes with Ki values ranging from 16.4 to greater than 3,000 nM in radioligand binding assays. LY334370 inhibits forskolin-induced cAMP accumulation in mouse L-M(TK-) cell membranes expressing the recombinant human 5-HT1F receptor (EC50 = 1.51 nM).{52209} It decreases electrically stimulated extravasation of plasma proteins in the dura mater in a guinea pig trigeminal nerve model of migraine headache.

• Artikelnummer: CAY29481-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29481-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK