LY344864 (hydrochloride), CAS 1217756-94-9

Formulation: A solid

Formal Name: N-[(3R)-3-(dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluoro-benzamide, monohydrochloride

Purity: ≥98%

Formula Markup: C21H22FN3O • HCl

Formula Weight: 387,9

Shelf life (days): 1460

CAS Number: 1217756-94-9

Notes: LY344864 is an agonist of the serotonin (5-HT) receptor subtype 5-HT1F (Ki = 6 nM).{53306} It is selective for 5-HT1F over 5-HT1A-E , 5-HT2A-C, and 5-HT7 receptors (Kis = 0.53-4.85 µM), as well as dopamine D1 and D2, GABAA, histamine H1, muscarinic, and α1-, α2-, and β-adrenergic receptors with Ki values ranging from 3.69 to greater than 100 µM. LY344864 inhibits forskolin-induced cAMP accumulation in L-M(TK-) cells expressing recombinant human 5-HT1F receptors with an EC50 value of 3 nM. It decreases electrically stimulated extravasation of plasma proteins in the dura mater in a rat trigeminal nerve model of migraine headache (ID50s = 0.6 and 2.1 ng/kg for i.v. and oral administration, respectively).

• Artikelnummer: CAY29496-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29496-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK