LY404187, CAS 211311-95-4

Formulation: A solid

Formal Name: N-[2-(4′-cyano[1,1′-biphenyl]-4-yl)propyl]-2-propanesulfonamide

Purity: ≥98%

Formula Markup: C19H22N2O2S

Formula Weight: 342,5

Shelf life (days): 1460

CAS Number: 211311-95-4

Notes: LY404187 is a benzothiadiazide positive allosteric modulator of AMPA receptors.{46485} It increases glutamate-induced activation of GluR1i, -2i, -2o, -3i, and -4i subunit-containing AMPA receptors with EC50 values of 5.65, 0.15, 1.44, 1.66, and 0.21 µM, respectively, in a calcium influx assay. LY404187 is selective for these AMPA receptors over GluR6 subunit-containing kainate receptors at 10 µM. LY404187 increases currents induced by glutamate and AMPA in rat prefrontal cortex pyramidal neurons (EC50s = 1.3 and 1.2 µM, respectively) but not in AMPA-stimulated primary rat embryonic hippocampal or primary cerebellar Purkinje neurons.{46486,46487} LY404187 prevents decreases in the number of dopaminergic neurons in the substantia nigra induced by MPTP and 6-OHDA (Item No. 25330) in mouse and rat, respectively, models of Parkinson’s disease when administered at a dose of 0.5 mg/kg per day.{46488}

• Artikelnummer: CAY28741-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28741-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK