Maprotiline-d3 (hydrochloride), CAS 1329496-63-0

Formulation: A solid

Formal Name: N-methyl-d3-9,10-ethanoanthracene-9(10H)-propanamine, monohydrochloride

Purity: ≥99% deuterated forms (d1-d3)

Formula Markup: C20H20D3N • HCl

Formula Weight: 316,9

Shelf life (days): 1460

CAS Number: 1329496-63-0

Notes: Maprotiline-d3 is intended for use as an internal standard for the quantification of maprotiline (Item No. 15892) by GC- or LC-MS. Maprotiline is a tricyclic antidepressant.{25873,22877} It binds to the norepinephrine transporter (NET; Kd = 11 nM) and is selective for NET over the serotonin (5-HT) and dopamine transporters (Kds = 5,800 and 1,000 nM, respectively).{22877} Maprotiline also binds to the 5-HT receptor subtype 5-HT2A (Ki = 51 nM), as well as histamine H1, muscarinic acetylcholine, α1-adrenergic, and dopamine D2 receptors (Kds = 2, 570, 90, and 350 nM, respectively).{25914} In vivo, maprotiline inhibits norepinephrine reuptake in rat brain and peripheral tissues.{59742} It reduces isolation-induced aggressive behavior and inhibits electrical foot-shock stimulation-induced belligerence in mice when administered at doses ranging from 3 to 10 mg/kg. Maprotiline (20 µM) prevents acid sphingomyelinase activation and subsequent ceramide release induced by infection with replication-deficient vesicular stomatitis virus pseudoviral particles (pp-VSV) presenting the severe acute respiratory coronavirus 2 (SARS-CoV-2) spike protein in Vero cells, an effect that can be overcome with exogenous application of C16 ceramide (Item No. 10681).{54655} Formulations containing maprotiline have been used in the treatment of depression and anxiety. This product is also available as an analytical reference material (Item Nos. 32702 / 33077).

• Artikelnummer: CAY33301-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33301-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung