Marcfortine A, CAS 75731-43-0

Formulation: A solid

Formal Name: (2'R,3'aS,9'aS,10'aS)-6',7',8',9',10',10'a-hexahydro-1',1',4,4,12'-pentamethyl-spiro[4H,8H-[1,4]dioxepino[2,3-g]indole-8,2'(3'H)-[1H,4H-3a,9a](iminomethano)cyclopenta[b]quinolizine]-9,11'(10H)-dione

Purity: ≥98%

Formula Markup: C28H35N3O4

Formula Weight: 477,6

Shelf life (days): 1460

CAS Number: 75731-43-0

Notes: Marcfortine A is an indole alkaloid originally isolated from P. roqueforti.{39450} It has nematocidal activity against the parasitic nematode H. contortus (LD99 = 0.06 μg/ml) and inhibits motility of adult worms (EC50 = 2 μM).{39451},{39453} Marcfortine A eliminates H. contortus, T. colubriformis, and O. ostertagi from experimentally infected jirds (ED95s = 0.33, 0.11, and 2.5 mg/animal, respectively).{39453} It dose-dependently inhibits nicotine-induced calcium mobilization in SH-SY5Y and TE-671 cells expressing α3 subunit-containing human nicotinic acetylcholine receptors (nAChRs) and muscle-type nAChRs, respectively.{39452}

• Artikelnummer: CAY23486-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23486-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK