MCC-555, CAS 161600-01-7

Formulation: A crystalline solid

Formal Name: 5-[[6-[(2-fluorophenyl)methoxy]-2-naphthalenyl]methyl]-2,4-thiazolidinedione

Purity: ≥98%

Formula Markup: C21H16FNO3S

Formula Weight: 381,4

Shelf life (days): 1460

CAS Number: 161600-01-7

Notes: The peroxisome proliferator-activated receptor-γ (PPARγ) is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones (TZDs), a group of structurally related synthetic agonists with antidiabetic actions in vivo.{7575,8930} Rosiglitazone (BRL49653) is a prototypical TZD and has served as a reference compound for this class.{8461} MCC-555 is a structural homolog of rosiglitazone and the other TZDs. MCC-555 binds with about 1/10 the affinity of rosiglitazone to PPARγ.{7413} Despite this, MCC-555 is a more potent antidiabetic agent in whole animal experiments than rosiglitazone and several other prototypic TZDs; the ED50 value in these experiments was 2.7 mg/kg for MCC-555 compared with 7.1 mg/kg for rosiglitazone. MCC-555 is therefore a unique new member of the TZD class and may be useful in differentiating some of the multiple activities attributed to this class of compounds.

• Artikelnummer: CAY70735-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 70735-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK