Notes: MCHB-1 is a potent agonist of the human cannabinoid 2 (CB2) receptor (EC50 = 0.52 nM) that shows high selectivity for CB2 over CB1 (Kis = 3.7 and 110 nM, respectively).{21225} Similar benzimidazole compounds significantly reduce peripheral pain with reduced central nervous system side effects in mice.{21221}