Formulation: A solid
Formal Name: 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-piperazine-2,2,3,3,5,5,6,6-d8, dihydrochloride
Purity: ≥99% deuterated forms (d1-d8)
Formula Markup: C25H19ClD8N2 • 2HCl
Formula Weight: 471,9
Shelf life (days): 1460
CAS Number: 1432062-16-2
Notes: Meclizine-d8 is intended for use as an internal standard for the quantification of meclizine (Item No. 14615) by GC- or LC-MS. Meclizine is a histamine H1 receptor antagonist (Ki = 250 nM).{23220} Pretreatment with meclizine (2.5-30 mg/kg, i.p.) reduces ovalbumin-induced mast cell degranulation, edema, and leukocyte influx in rat lung.{46070} Formulations containing meclizine have been used in the treatment of motion sickness and vertigo.