Metamizole-d3 (sodium salt), CAS 2512223-60-6

Formulation: A solid

Formal Name: ((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl-d3)amino)methanesulfonate, monosodium salt

Purity: ≥99% deuterated forms (d1-d3)

Formula Markup: C13H13D3N3O4S • Na

Formula Weight: 336,4

Shelf life (days): 1460

CAS Number: 2512223-60-6

Notes: Metamizole-d3 is intended for use as an internal standard for the quantification of metamizole (Item No. 15771) by GC- or LC-MS. Metamizole is a nonopioid prodrug that is rapidly hydrolyzed to the analgesic and antipyretic metabolites 4-methylaminoantipyrine (MAA) and 4-aminoantipyrine (AA).{25749} It inhibits COX-1 and COX-2 activity (IC50 = ~150 µg/ml for both in cell-free assays), as well as reduces increases in intracellular calcium levels induced by the TRPA1 agonist AITC in isolated rat and mouse dorsal root ganglia and IMR-90 human fibroblasts (IC50s = 30-91 µM in patch-clamp assays).{46639,46640} Metamizole (6, 12, and 25 µg/ml) inhibits ADP- and epinephrine-induced platelet aggregation in human platelet-rich plasma (hPRP).{46641} It prevents fever induced by LPS, TNF-α, and IL-6, but not arachidonic acid (Item Nos. 90010 / 90010.1 / 10006607) or prostaglandin E2 (PGE2; Item No. 14010), in rats when administered at a dose of 120 mg/kg.{46642} Metamizole (250 and 500 mg/kg) increases the paw withdrawal threshold in the paw pressure test, indicating analgesic activity, in rat models of carrageenan-induced acute pain and postoperative incision pain.{46643}

• Artikelnummer: CAY26496
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 26496-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung