Methapyrilene (hydrochloride), CAS 135-23-9

Formulation: A crystalline solid

Formal Name: N1,N1-dimethyl-N2-2-pyridinyl-N2-(2-thienylmethyl)-1,2-ethanediamine, monohydrochloride

Purity: ≥98%

Formula Markup: C14H19N3S • HCl

Formula Weight: 297,8

Shelf life (days): 1460

CAS Number: 135-23-9

Notes: Methapyrilene is a histamine H1 receptor antagonist (Ki = 4.5 nM) and non-genotoxic carcinogen.{23220,61262} Dietary administration of methapyrilene (0.1%) induces liver tumors in rats, with greater than 50% of rats incurring distant metastases.{61263} It decreases the acetylation of histone 3 lysine 9 (H3K9) and H3K56, as well as the di- and trimethylation of H3K4 and H4K20, respectively, in rat liver when administered at 40 mg/kg per day for six weeks.{61262} Methapyrilene also increases 4-hydroxy nonenal (4-NHE) protein adducts in rat liver. Formulations containing methapyrilene were previously used as sleep aids.

• Artikelnummer: CAY33434-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33434-100
• Green Labware: Nein
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK