Methiothepin (maleate), CAS 19728-88-2

Formulation: A crystalline solid

Formal Name: 1-[10,11-dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl]-4-methyl-piperazine, (2Z)-butenedioate

Purity: ≥98%

Formula Markup: C20H24N2S2 • C4H4O4

Formula Weight: 472,6

Shelf life (days): 1460

CAS Number: 19728-88-2

Notes: Methiothepin is a non-selective antagonist of the serotonin (5-HT) receptor.{39327} It is a potent antagonist of 5-HT1A and 5-HT1B (IC50 = 16 nM and Ki = 0.2 nM, respectively) as well as 5-HT2A, 5-HT2B, and 5-HT2C receptors (Kis = 3.16, 2.08, and 4.46 nM, respectively).{40435,40434,41063} Methiothepin binds to 5-HT5A, 5-HT5B, 5-HT6, and 5-HT7 receptors with Kd values of 100, 15.8, 1.8, and 1 nM, respectively.{39327} It has been used to characterize the role of serotonin in various biological processes, including renal vasodilation and gastrointestinal function.{40402,40436}

• Artikelnummer: CAY23138-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23138-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK