Metoclopramide-d3, CAS 1216522-89-2

Formulation: A solid

Formal Name: 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-(methoxy-d3)benzamide

Purity: ≥99% deuterated forms (d1-d3)

Formula Markup: C14H19ClD3N3O2

Formula Weight: 302,8

Shelf life (days): 1460

CAS Number: 1216522-89-2

Notes: Metoclopramide-d3 is intended for use as an internal standard for the quantification of metoclopramide (Item No. 23360) by GC- or LC-MS. Metoclopramide is an orally bioavailable serotonin (5-HT) receptor 5-HT3 antagonist with Ki and IC50 values of 995 and 308 nM, respectively, in rat cortical membranes.{36215,36216} It is also a dopamine D2 receptor antagonist (IC50 = 483 nM in rat brain synaptic membranes).{36216} Oral administration of metoclopramide inhibits emesis induced by cisplatin (Item No. 13119) and apomorphine (Item No. 16094) in ferrets and dogs with ED50 values of 6.17 and 0.45 mg/kg, respectively.{36215,36216} Metoclopramide reversibly inhibits human acetylcholinesterase (AChE) isolated from the caudate nucleus (Kis = 9.3 and 82 μM for competitive and non-competitive inhibition, respectively).{36217} Formulations containing metoclopramide have been used as anti-emetic and antipsychotic agents.{36218,36219}

• Artikelnummer: CAY28885-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28885-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung