Metoclopramide (hydrochloride), CAS 7232-21-5

Formulation: A crystalline solid

Formal Name: 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-benzamide, monohydrochloride

Purity: ≥98%

Formula Markup: C14H22ClN3O2 • HCl

Formula Weight: 336,3

Shelf life (days): 1460

CAS Number: 7232-21-5

Notes: Metoclopramide is an orally bioavailable serotonin (5-HT) receptor 5-HT3 antagonist with Ki and IC50 values of 995 and 308 nM, respectively, in rat cortical membranes.{36215,36216} It is also a dopamine D2 receptor antagonist (IC50 = 483 nM in rat brain synaptic membranes).{36216} Oral administration of metoclopramide inhibits emesis induced by cisplatin (Item No. 13119) and apomorphine (Item No. 16094) in ferrets and dogs with ED50 values of 6.17 and 0.45 mg/kg, respectively.{36215,36216} Metoclopramide reversibly inhibits human acetylcholinesterase (AChE) isolated from the caudate nucleus (Kis = 9.3 and 82 μM for competitive and non-competitive inhibition, respectively).{36217} Formulations containing metoclopramide have been used as anti-emetic and antipsychotic agents.{36218,36219}

• Artikelnummer: CAY23360-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23360-10
• Green Labware: Nein
• Verpackungseinheit: 10 g
• Mengeneinheit: STK