Metoprolol-d6 (tartrate)

Formulation: A solid

Formal Name: 1-[4-(2-methoxyethyl)phenoxy]-3-[[1-(methyl-d3)ethyl-2,2,2-d3]amino]-2-propanol, 2R,3R-dihydroxybutanedioate (2:1)

Purity: ≥99% deuterated forms (d1-d6)

Formula Markup: C15H19D6NO3 • 1/2C4H6O6

Formula Weight: 348,5

Shelf life (days): 730

Notes: Metoprolol-d6 is intended for use as an internal standard for the quantification of metoprolol (Item No. 15429) by GC- or LC-MS. Metoprolol is a β1-adrenergic receptor (β1-AR) antagonist (Ki = 47 nM in CHO cells expressing the human receptor).{25395} It is selective for β1- over β2- and β3-ARs (Kis = 2,730 and >10,000 nM, respectively, in CHO cells expressing the human receptors). Metoprolol (4.7 µM) reduces GTP-induced adenylyl cyclase (AC) activity in CHO cells expressing β1- and β2-ARs. It reduces pulse rate in isolated rat atria in a concentration-dependent manner.{51268} Metoprolol (10 mg/kg) reduces increased heart rate and mean arterial pressure (MAP) in a rat model of systolic hypertension induced by a fructose-rich diet. Formulations containing metoprolol have been used in the treatment of exercised-induced hypertension, angina, and tachycardia.

• Artikelnummer: CAY28188-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28188-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung