Migrastatin, CAS 314245-65-3

Formulation: A solid

Formal Name: 4-[(5S)-5-[(2R,3Z,5R,6S,7S,8E,12E)-6-hydroxy-7-methoxy-3,5-dimethyl-14-oxooxacyclotetradeca-3,8,12-trien-2-yl]-4-oxohexyl]-2,6-piperidinedione

Purity: ≥90%

Formula Markup: C27H39NO7

Formula Weight: 489,6

Shelf life (days): 1460

CAS Number: 314245-65-3

Notes: Migrastatin is a bacterial metabolite that has been found in Streptomyces with antimuscarinic and anticancer activities.{60281,60282} It binds to M1-5 muscarinic acetylcholine receptors (Kis = >200, 200, 31, 43, and >200 µM, respectively) and inhibits calcium mobilization induced by carbamoylcholine (carbachol; Item No. 14486) in SK-N-SH cells (IC50 = 28 µM), as well as in primary rat bladder smooth muscle cells.{60281} Migrastatin inhibits the migration of EC17 esophageal cancer cells in a wound healing assay (IC50 = 10 µg/ml) and 4T1 mouse mammary carcinoma cells in a chamber cell migration assay (IC50 = 29 µM).{60282} It enhances cytotoxicity induced by vinblastine (Item No. 11762) in vincristine-resistant P388/VCR cells.{60283}

• Artikelnummer: CAY32885
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 32885-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK