Mizolastine, CAS 108612-45-9

Formulation: A crystalline solid

Formal Name: 2-[[1-[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]-4-piperidinyl]methylamino]-4(3H)-pyrimidinone

Purity: ≥98%

Formula Markup: C24H25FN6O

Formula Weight: 432,5

Shelf life (days): 1460

CAS Number: 108612-45-9

Notes: Mizolastine is a histamine H1 receptor antagonist (Ki = 0.001 µM).{54289} It is selective for histamine H1 over histamine H2 and H3 receptors (Kis = >100 µM for both), as well as the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D, 5-HT2, and 5-HT3, dopamine D1 and D2, α1- and α2-adrenergic, adenosine, and muscarinic receptors in radioligand binding assays (Kis = >1 µM for all). Mizolastine (0.1, 0.3, and 1 mg/kg) reduces histamine release from bronchial mast cells in ovalbumin-sensitized guinea pigs. It reduces histamine-induced paw edema in rats, skin edema in dogs, and bronchoconstriction in guinea pigs (ED50s = 0.5, 0.07, and 0.03 mg/kg, respectively). Mizolastine also inhibits passive cutaneous anaphylaxis, as well as lethal shock induced by compound 48/80 (Item No. 22173) in rats (ED50s = 1.6 and 0.07 mg/kg, respectively). Formulations containing mizolastine have been used in the treatment of allergic rhinitis and urticaria.

• Artikelnummer: CAY9000566-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 9000566-5
• Green Labware: Nein
• Verpackungseinheit: 5 g
• Mengeneinheit: STK