MK-0557, CAS 328232-95-7

Formulation: A crystalline solid

Formal Name: trans-N-[1-(2-fluorophenyl)-1H-pyrazol-3-yl]-1'-oxo-spiro[cyclohexane-1,3'(1'H)-furo[3,4-c]pyridine]-4-carboxamide

Purity: ≥98%

Formula Markup: C22H19FN4O3

Formula Weight: 406,4

Shelf life (days): 1460

CAS Number: 328232-95-7

Notes: MK-0557 is a potent antagonist of the neuropeptide Y (NPY) receptor Y5 (Kis = 1.3, 0.79, 0.74, and 1.4 nM for human, rhesus monkey, mouse, and rat receptors, respectively).{35182} It is >7,500-fold selective for Y5 over other receptors and lacks activity in a panel of 180 receptors, enzymes, and ion channels at concentrations up to 1 μM. MK-0557 increases intracellular calcium in CHO cells expressing the human Y5 receptor in a concentration-dependent manner. In vivo, MK-0557 (30 mg/kg) reduces body weight gain in wild-type and diet-induced obese mice. It also reduces retroperitoneal fat pad weight, epididymal and mesenteric fat pad weights, leptin levels, and food intake in lean mice fed a high-fat diet.

• Artikelnummer: CAY22134-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 22134-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK