MK-1903, CAS 1268882-43-4

Formulation: A solid

Formal Name: 4,4aR,5,5aR-tetrahydro-1H-cyclopropa[4,5]cyclopenta[1,2-c]pyrazole-3-carboxylic acid

Purity: ≥98%

Formula Markup: C8H8N2O2

Formula Weight: 164,2

Shelf life (days): 1460

CAS Number: 1268882-43-4

Notes: MK-1903 is an agonist of hydroxycarboxylic acid receptor 2 (HCA2), known previously as G protein-coupled receptor 109A (GPR109A).{60589} It reduces forskolin-induced cAMP production in a homogenous time-resolved fluorescence (HTRF) assay using CHO cells expressing the human receptor (EC50 = 12.9 nM). MK-1903 is selective for HCA2 over a panel of G protein-coupled receptors (GPCRs) and ion channels (IC50s = >10 µM for all). It reduces plasma free fatty acid levels in fasted rats when administered at doses ranging from 0.001 to 100 mg/kg.

• Artikelnummer: CAY34304-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 34304-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK