MK-4101, CAS 935273-79-3

Formulation: A crystalline solid

Formal Name: 5-(3,3-difluorocyclobutyl)-3-[4-[4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl]bicyclo[2.2.2]oct-1-yl]-1,2,4-oxadiazole

Purity: ≥98%

Formula Markup: C24H24F5N5O

Formula Weight: 493,5

Shelf life (days): 1460

CAS Number: 935273-79-3

Notes: MK-4101 is a Smoothened (Smo) receptor antagonist.{48932} It binds to human recombinant Smo expressed in HEK293T cells (IC50 = 1.1 µM) and inhibits Gli1-mediated hedgehog signaling in a reporter assay (IC50 = 1.5 µM). It is also an inhibitor of 11β-hydroxy steroid dehydrogenase-1. MK-4101 (40 and 80 mg/kg per day) reduces tumor growth in a murine medulloblastoma mouse allograft model, induces tumor regression when administered at a dose of 80 mg/kg twice per day, and reduces expression of the hedgehog pathway-associated transcription factor Gli1 in tumor tissue.

• Artikelnummer: CAY29159-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29159-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK