ML-18, CAS 1422269-30-4

Formulation: A solid

Formal Name: (αS)-N-[[1-(4-methoxyphenyl)cyclohexyl]methyl]-α-[[[(4-nitrophenyl)amino]carbonyl]amino]-1H-indole-3-propanamide

Purity: ≥98%

Formula Markup: C32H35N5O5

Formula Weight: 569,7

Shelf life (days): 1460

CAS Number: 1422269-30-4

Notes: ML-18 is a non-peptide bombesin receptor subtype 3 (BB3) antagonist that inhibits [125I]BA1 binding to NCI-H1299 lung cancer cells transfected with human BB3 receptors (IC50 = 4.8 μM).{47246} It is selective for BB3 over the gastrin releasing peptide receptor (GRPR) and the neuromedin B receptor (NMBR) with IC50 values of 16 and >100 μM, respectively, in a radioligand binding assay. ML-18 (16 μM) reversibly inhibits BA1-induced increases in cytosolic calcium in NCI-H1299 cells. It also inhibits BA1-induced phosphorylation of ERK and EGFR and reduces proliferation of NCI-H1299 cells.

• Artikelnummer: CAY27319-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 27319-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK