ML-382, CAS 1646499-97-9

Formulation: A solid

Formal Name: 2-[(cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)-benzamide

Purity: ≥98%

Formula Markup: C18H20N2O4S

Formula Weight: 360,4

Shelf life (days): 1460

CAS Number: 1646499-97-9

Notes: ML-382 is a positive allosteric modulator of MAS-related G protein-coupled receptor family member X1 (MRGPRX1).{64672} It potentiates activation of MRGPRX1 induced by the MRGPRX1 agonist BAM 22P (8-22) (Item No. 35263) in HEK293 cells expressing the human receptor (EC50 = 0.19 µM) but does not potentiate activation of MRGPRX2 induced by the MRGPRX2 agonist proadrenomedullin (PAMP) in HEK293 cells expressing the human receptor at 5 µM. ML-382 is also selective for MRGPRX1 over a panel of 68 G protein-coupled receptors (GPCRs), ion channels, and transporters at 10 µM. It enhances inhibition of high-voltage-activated calcium currents (ICa ) induced by BAM 22P (8-22) in dorsal root ganglion neurons isolated from transgenic mice expressing human MRGPRX1 when used at a concentration of 5 µM.{64673} Intrathecal administration of ML-382 (25 µM/animal) decreases formalin-induced paw licking and shaking in MRGPRX1 transgenic mice.

• Artikelnummer: CAY36668-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36668-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe