MLS-1547, CAS 315698-36-3

Formulation: A crystalline solid

Formal Name: 5-chloro-7-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-8-quinolinol

Purity: ≥98%

Formula Markup: C19H19ClN4O

Formula Weight: 354,8

Shelf life (days): 1460

CAS Number: 315698-36-3

Notes: MLS-1547 is a G protein-biased agonist of dopamine D2 receptors (EC50 = 0.37 μM in a calcium mobilization assay).{42964} It inhibits forskolin-induced cAMP accumulation in CHO cells expressing human D2 receptors (EC50 = 0.26 μM) but is inactive in β-arrestin recruitment assays. MLS-1547 antagonizes dopamine-induced β-arrestin recruitment in cell-based assays with IC50 values ranging from 3.8 to 9.9 μM.{42964} It is also an inhibitor of type II secretion in Gram-negative bacteria.{42965} MLS-1547 inhibits secretion of phospholipase C (PlcH/N) and the virulence factor elastase (LasB) from P. aeruginosa (IC50s = 15 and 13 μM, respectively) and inhibits B. pseudomallei protease secretion by 90.8% when used at a concentration of 25 μM.

• Artikelnummer: CAY27648-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 27648-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK